Publications & Reports

Insights and controversies into the role of the key Apicomplexan invasion ligand, Apical Membrane Antigen 1.

Harvey KL, Yap A, Gilson PR, Cowman AF, Crabb BS
Centre for Biomedical Research, Burnet Institute, 85 Commercial Road, Melbourne, Victoria 3004, Australia; Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria 3010, Australia.


Apicomplexan parasites are obligate intracellular pathogens that cause a host of human and animal diseases. These parasites have developed a universal mechanism of invasion involving formation of a ‘moving junction’ (MJ) that provides a stable anchoring point through which the parasite invades host cells. The composition of the MJ, particularly the presence of the protein Apical Membrane Antigen 1 (AMA1), has recently been the subject of some controversy. In this commentary we review findings that led to the current model of the MJ complex and dissect the major conflicts to determine whether a substantial reassessment of the role of AMA1 is justified.

Full text of this open-access article can be obtained at the link on right hand side of this page or at the publisher’s web site at


  • Journal: International Journal for Parasitology
  • Published: 22/08/2014
  • Volume: 44
  • Issue: 12
  • Pagination: 853-857


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