Publications & Reports

FcgammaRI-deficient mice show multiple alterations to inflammatory and immune responses.

Barnes N, Gavin AL, Tan PS, Mottram P, Koentgen F, Hogarth PM
The Austin Research Institute, Kronheimer Building, Studley Road, Heidelberg, Victoria 3084, Australia.

Abstract

The inactivation of the mouse high-affinity IgG Fc receptor FcgammaRI resulted in a wide range of defects in antibody Fc-dependent functions. These studies showed the primary importance of FcgammaRI in endocytosis of monomeric IgG, kinetics, and extent of phagocytosis of immune complexes, in macrophage-based ADCC, and in immune complex-dependent antigen presentation to primed T cells. In the absence of FcgammaRI, antibody responses were elevated, implying the removal of a control point by the deletion of FcgammaRI. In addition, FcR-gamma chain-deficient mice were found to express partially functional FcgammaRI. Thus, FcgammaRI is an early participant in Fc-dependent cell activation and in the development of immune responses.

Publication

  • Journal: Immunity
  • Published: 01/03/2002
  • Volume: 16
  • Issue: 3
  • Pagination: 379-389

Authors