Publications & Reports

Identification of four different CD46 (MCP) molecules with anti-peptide antibodies.

Purcell DF, Jonstone RW, McKenzie IF
Austin Research Institute, Austin Hospital, Heidelberg, Victoria, Australia.


Four protein isoforms of the human CD46 molecule (MCP) have been identified using rabbit antisera against synthetic peptides corresponding to predicted cytoplasmic carboxyl-terminal sequences. Two different cytoplasmic tails, CD46 CYT 1 and CD46 CYT 2, were detected in CD46 molecules isolated from almost every cell type examined. Bands of 56 and 66 kDa were obtained from SDS-PAGE analyses of various cell types with both CYT 1 and CYT 2 antisera, which indicated that the size polymorphism of the CD46 molecule is not due to variations in the cytoplasmic tail and that each species contained two different sized molecules.


  • Journal: Biochemical and Biophysical Research Communications
  • Published: 31/10/1991
  • Volume: 180
  • Issue: 2
  • Pagination: 1091-1097