Publications & Reports

HIV and age do not substantially interact in HIV-associated neurocognitive impairment.

Lucette A Cysique, Paul Maruff, Margaret P Bain, Edwina Wright, Bruce J Brew
Neurology Department, Xavier Building, Level 4, St. Vincent's Hospital, Darlinghurst, Sydney 2010, NSW, Australia.


The authors investigated the combined age and HIV effects on cognitive functions in 146 individuals, 116 of whom had HIV infection. Forty-two percent had HIV-associated neurocognitive disorder, and all were receiving highly active antiretroviral therapy. Using linear and nonlinear regression modeling, the authors found only a trending effect of the quadratic term HIV status x age, both including dementia cases (p=0.12) and excluding dementia cases (p<0.06). Our results suggest that either this early-2000 cohort is not old enough to detect a clear interactive age and HIV effect or that there may be a survivor bias for individuals with long-term infection. Further longitudinal studies are warranted.


  • Journal: The Journal of Neuropsychiatry and Clinical Neurosciences
  • Published: 01/01/2011
  • Volume: 23
  • Issue: 1
  • Pagination: 83-89