Publications & Reports

DEC-205 is a cell surface receptor for CpG oligonucleotides (Review)

Caminschi I, Meuter S, Heath WR
Centre for Immunology; Burnet Institute; Melbourne, VIC Australia ; The Walter and Eliza Hall Institute of Medical Research; Parkville, VIC Australia ; Department of Microbiology and Immunology; University of Melbourne; Melbourne, VIC Australia.

Abstract

We have recently demonstrated that synthetic CpG oligonucleotides (ODNs), which function as potent immunostimulators, bind to the multi-lectin receptor DEC-205, resulting in their internalization. DEC-205-deficient mice exhibit impaired dendritic-cell and B-cell maturation, impaired cytokine responses and suboptimal cytotoxic T-cell responses. As murine and human DEC-205 are highly conserved, CpG ODNs destined to clinical applications should be designed to maximize DEC-205 binding.

Publication

  • Journal: Oncoimmunology
  • Published: 01/03/2013
  • Volume: 2
  • Issue: 3
  • Pagination: e23128