Publications & Reports

Receptor-Specific Delivery of Protein Antigen to Dendritic Cells by a Nanoemulsion Formed Using Top-Down Non-Covalent Click Self-Assembly.

Zeng BJ, Chuan YP, O'Sullivan B, Caminschi I, Lahoud MH, Thomas R, Middelberg AP
The University of Queensland, Australian Institute for Bioengineering and Nanotechnology, St Lucia QLD 4072, Australia.

Abstract

A new class of targeted and immune-evading nanocarrier made using only biological components and facile processes is assembled in a bottom-up fashion. Simple top-down sequential addition of immune-evading or receptor-specific antibody elements conjugated to biosurfactant protein DAMP4 promotes self-assembly at an interface previously formed in the presence of peptide surfactant AM1, leading to a functional display at the interface through non-covalent molecular self-assembly.

Publication

  • Journal: Small
  • Published: 18/04/2013
  • Volume: 9
  • Issue: 22
  • Pagination: 3735