Publications & Reports

Induction of CD8+ T cells using heterologous prime-boost immunisation strategies.

Schneider J, Gilbert SC, Hannan CM, Dégano P, Prieur E, Sheu EG, Plebanski M, Hill AV
Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, UK. [email protected]


One of the current challenges in vaccine design is the development of antigen delivery systems or vaccination strategies that induce high protective levels of CD8+ T cells. These cells are crucial for protection against certain tumours and intracellular pathogens such as the liver-stage parasite of malaria. A liver-stage malaria vaccine should therefore include CD8+ T-cell-inducing components. This review provides an overview of prime-boost immunisation strategies that result in protective CD8+ T-cell responses against malaria with an emphasis on work from our laboratory. Possible mechanisms explaining why heterologous prime-boost strategies, in particular boosting with replication-impaired recombinant poxviruses, are so effective are discussed.


  • Journal: Immunological Reviews
  • Published: 01/08/1999
  • Volume: 170
  • Pagination: 29-38