Publications & Reports

Surfactant protein A binds to the fusion glycoprotein of respiratory syncytial virus and neutralizes virion infectivity.

Ghildyal R, Hartley C, Varrasso A, Meanger J, Voelker DR, Anders EM, Mills J
Department of Microbiology, University of Melbourne, Parkville, Victoria, Australia.

Abstract

Collectins are a family of calcium-dependent collagenous lectins that appear to be important in innate host defense. We investigated the ability of three human collectins, namely, lung surfactant proteins A (SP-A) and D (SP-D) and the serum mannose-binding protein (MBP), to bind to the surface glycoproteins of respiratory syncytial virus (RSV). SP-A was shown to bind to the F (fusion) glycoprotein but not to the viral G (attachment) glycoprotein, and binding was completely abrogated in the presence of EDTA. Neither SP-D nor MBP bound to either glycoprotein. SP-A also neutralized RSV in a calcium dependent fashion. These results support a role for SP-A in the defense of infants against infection with RSV and indicate a possible mechanism for its protective activity.

Publication

  • Journal: The Journal of Infectious Diseases
  • Published: 01/12/1999
  • Volume: 180
  • Issue: 6
  • Pagination: 2009-2013