Publications & Reports

A role for P-glycoprotein in regulating cell death.

Johnstone RW, Ruefli AA, Tainton KM, Smyth MJ
Cellular Cytotoxicity Laboratory, The Austin Research Institute, Australia, Victoria. [email protected]


P-glycoprotein (P-gp) is an energy dependent drug pump responsible for multidrug resistance (MDR) in human cancers. While it is irrefutable that P-gp can efflux xenobiotics out of cells, the biological function of P-gp in multicellular organisms has yet to be firmly established. The question of what, if anything, P-gp does when not effluxing drugs has been raised by recent reports indicating that P-gp may regulate apoptosis, chloride channel activity, cholesterol metabolism and immune cell function. There is now a lively debate regarding the possible role of P-gp in regulating cell differentiation, proliferation and survival.


  • Journal: Leukemia & Lymphoma
  • Published: 01/06/2000
  • Volume: 38
  • Issue: 1-2
  • Pagination: 1-11