Publications & Reports

Multiple physiological functions for multidrug transporter P-glycoprotein?

Johnstone RW, Ruefli AA, Smyth MJ
Cellular Cytotoxicity Laboratory, The Austin Research Institute, Austin Hospital, Studley Road, Heidelberg 3084, Victoria, Australia. [email protected]


Multidrug resistance mediated by the drug-efflux protein P-glycoprotein (P-gp) is one mechanism that tumor cells use to escape death induced by chemotherapeutic drugs. Although it is irrefutable that P-gp can efflux xenobiotics out of cells, biological regulatory functions for P-gp in multicellular organisms have yet to be established firmly. Recent observations have challenged the notion that P-gp has evolved merely to efflux xenotoxins out of healthy cells and raised the possibility that P-gp and related transporter molecules might play a fundamental role in regulating cell differentiation, proliferation and survival.


  • Journal: Trends in Biochemical Sciences
  • Published: 01/01/2000
  • Volume: 25
  • Issue: 1
  • Pagination: 1-6