Publications & Reports

Structural implications for the design of molecular vaccines.

Apostolopoulos V, Yu M, McKenzie IF, Wilson IA
Department of Molecular Biology and Skaggs Institute for Chemical Biology (BCC-206), Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA. vapos@scripps.edu

Abstract

The major histocompatibility complex molecules bind and present short antigenic peptide fragments on the surface of antigen presenting cells to T-cell receptors. Recognition of peptide-MHC by cytotoxic T-cells initiates a cascade of signals to T-cells, which in turn destroy the antigen presenting cell. In the design of molecular vaccines for the treatment of diseases, an understanding of the 3-dimensional structure of MHC class I and is interaction with both peptide and T-cell receptor is an important prerequisite. In this review, we will discuss such crystal structures, as well as structures of glycopeptides and alternative T-cell antigens presented by MHC molecules.

Publication

  • Journal: Current Opinion in Molecular Therapeutics
  • Published: 01/02/2000
  • Volume: 2
  • Issue: 1
  • Pagination: 29-36