Publications & Reports

Coreceptors and HIV-1 pathogenesis.

Gorry PR, Ancuta P
Center for Virology, Burnet Institute, Melbourne, Victoria, Australia. gorry@burnet.edu.au

Abstract

The major HIV-1 coreceptors, CCR5 and CXCR4, mediate virus entry into CD4+ cells and are therefore a critical component of the HIV-1 life cycle. Alterations in coreceptor preference as well as the efficiency and mechanism of interaction between HIV-1 and CCR5 and/or CXCR4 has a significant influence on viral tropism, progression of disease, and response to coreceptor antagonists. In addition, these alterations influence the susceptibility of CD4+ T-cell, monocyte, and dendritic cell subsets to infection and therefore, are important for several facets of HIV-1 pathogenesis including the establishment of latent reservoirs, trafficking, and transmission. This review highlights recent literature that has advanced our understanding of the role of coreceptors in HIV-1 pathogenesis.

Publication

  • Journal: Current HIV/AIDS Reports
  • Published: 01/03/2011
  • Volume: 8
  • Issue: 1
  • Pagination: 45-53