Publications & Reports

Ly6d-L, a cell surface ligand for mouse Ly6d.

Apostolopoulos J, McKenzie IF, Sandrin MS
Molecular Immunogenetics and Transplantation Laboratory, Austin Research Institute, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia. j.apostolopoulos@ari.unimelb.edu.au

Abstract

The mouse Ly6 gene family encodes proteins found in lymphocytes and other cells. Some are involved in cell activation; no ligands have been found. A ligand for Ly6d (ThB) was identified on lymphocytes using microspheres loaded with Ly6d and the cDNA isolated from a spleen/thymus library by panning on Ly6d. The Ly6d ligand (Ly6d-L) is a nonglycosylated protein of 9 kDa of broad distribution, rich in cysteine, with no discernable transmembrane sequence. Its N and C termini are on the cell surface, where it associates with a 30 kDa protein. Ly6d-L is homologous with an EGF repeat of Notch.

Publication

  • Journal: Immunity
  • Published: 01/02/2000
  • Volume: 12
  • Issue: 2
  • Pagination: 223-232