Publications & Reports

The development of a plant-based vaccine for measles.

Webster DE, Thomas MC, Huang Z, Wesselingh SL
Children's Vaccines Group, MacFarlane Burnet Institute for Medical Research and Public Health, P.O. Box 2284, Melbourne, Vic. 3001, Australia. diane@burnet.edu.au

Abstract

Plant-based vaccination strategies have the potential to overcome the limitations of the current measles vaccine. The measles virus hemagglutinin (MV-H) protein has been expressed in tobacco. Oral immunisation of mice with plant-derived MV-H protein resulted in MV-specific antibodies and secretory IgA, indicative of humoral and mucosal immune responses. In addition, boosting with oral plant-derived MV-H protein following a MV-H DNA prime, resulted in a greater response than could be induced with either vaccine alone. Collectively, this research represents a significant step towards an effective oral measles vaccine that would be temperature-stable, easy to administer and amenable to inexpensive manufacture.

Publication

  • Journal: Vaccine
  • Published: 07/03/2005
  • Volume: 23
  • Issue: 15
  • Pagination: 1859-1865