Publications & Reports

HIV-1 infection of monocyte-derived macrophages reduces Fc and complement receptor expression.

Kent SJ, Stent G, Sonza S, Hunter SD, Crowe SM
AIDS Pathogenesis Research Unit, Macfarlane Burnet Centre for Medical Research, Fairfield, Australia.

Abstract

Fc receptor (FcR) and complement receptor (CR) expression on HIV-infected monocyte-derived macrophages may be an important determinant of immune function. We studied the effects of HIV-1 infection of macrophages in vitro on FcR and CR expression. Macrophages were infected with HIV-1DV 7 days following isolation, and the expression of Fc gamma RI-III and CR3 were measured at intervals thereafter by flow cytometry. We found a reduction in receptor expression with the percentage of cells expressing FcRI 14 days post infection declining from 77% to 13%, FcRII fell from 96% to 85%, FcRIII from 45% to 9%, and CR3 from 91% to 67% 14 days following infection. As these receptors are important for macrophage function, their down-modulation may contribute to the pathogenesis of HIV-related disease.

Publication

  • Journal: Clinical and Experimental Immunology
  • Published: 01/03/1994
  • Volume: 95
  • Issue: 3
  • Pagination: 450-454

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