Publications & Reports

Roles of the NF-kappaB pathway in lymphocyte development and function.

Gerondakis S, Siebenlist U
The Burnet Institute, 85 Commercial Rd, Prahran, Victoria 3004, Australia. gerondakis@burnet.edu.au

Abstract

This article focuses on the functions of NF-kappaB that vitally impact lymphocytes and thus adaptive immunity. NF-kappaB has long been known to be essential for many of the responses of mature lymphocytes to invading pathogens. In addition, NF-kappaB has important functions in shaping the immune system so it is able to generate adaptive responses to pathogens. In both contexts, NF-kappaB executes critical cell-autonomous functions within lymphocytes as well as within supportive cells, such as antigen-presenting cells or epithelial cells. It is these aspects of NF-kappaB’s physiologic impact that we address in this article.

Publication

  • Journal: Cold Spring Harbor Perspectives in Biology
  • Published: 01/05/2010
  • Volume: 2
  • Issue: 5
  • Pagination: a000182