Publications & Reports

Uncoating kinetics of hepatitis A virus virions and provirions.

Bishop NE, Anderson DA
Hepatitis Research Unit, Macfarlane Burnet Centre for Medical Research, Fairfield, Victoria, Australia 3078. [email protected]

Abstract

When the growth kinetics of immature hepatitis A virus provirions and mature virions were monitored, distinct eclipse phases were noted for both types of particles. Strikingly, uncoating of virions occurred around 4 h postinfection, while uncoating of provirions occurred predominantly between 8 and 10 h postinfection. It is proposed that the heterogeneous mixture of infectious hepatitis A virus particles (virions and provirions) typically present in inocula is responsible for the normally asynchronous nature of hepatitis A virus uncoating kinetics.

Publication

  • Journal: Journal of Virology
  • Published: 01/04/2000
  • Volume: 74
  • Issue: 7
  • Pagination: 3423-3426

Author

Health Issues