Publications & Reports

Restrictive events in the replication of hepatitis A virus in vitro.

D A Anderson, S A Locarnini, A G Coulepis, I D Gust


Hepatitis A virus was purified from the feces of 2 patients with unrelated, naturally acquired infections and was inoculated into FRhK-4 cells. Analysis of protein synthesis by double-label coelectrophoresis and subtraction allowed the resolution of virus-specific proteins synthesized during infection. In FRhK-4 cells the two strains of virus studied produced markedly different profiles of virus-specified proteins, with an accumulation of high-molecular-weight proteins for strain HM790 relative to strain HM175, suggesting a level of restriction in the processing of the viral polyprotein.


  • Journal: Intervirology
  • Published: 01/01/1995
  • Volume: 24
  • Issue: 1
  • Pagination: 26-32


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