Publications & Reports

The adhesion of Plasmodium falciparum-infected erythrocytes to chondroitin sulfate A is mediated by P. falciparum erythrocyte membrane protein 1.

J C Reeder, A F Cowman, K M Davern, J G Beeson, J K Thompson, S J Rogerson, G V Brown
The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria 3050, Australia. reeder@wehi.edu.au

Abstract

Chondroitin sulfate A (CSA) is an important receptor for the sequestration of Plasmodium falciparum in the placenta, but the parasite ligand involved in adhesion has not previously been identified. Here we report the identification of a var gene transcribed in association with binding to CSA and present evidence that the P. falciparum erythrocyte membrane protein 1 product of the gene is the parasite ligand mediating CSA binding. Description of this gene and the implication of P. falciparum erythrocyte membrane protein 1 as the parasite ligand paves the way to a more detailed understanding of the pathogenesis of placental infection and potential therapeutic strategies targeting the interaction.

Publication

  • Journal: Proceedings of the National Academy of Sciences of the United States of America
  • Published: 27/04/1999
  • Volume: 96
  • Issue: 9
  • Pagination: 5198-5202

Author

Health Issue