Publications & Reports

CD16+ monocyte subset preferentially harbors HIV-1 and is expanded in pregnant Malawian women with Plasmodium falciparum malaria and HIV-1 infection.

Jaworowski A, Kamwendo DD, Ellery P, Sonza S, Mwapasa V, Tadesse E, Molyneux ME, Rogerson SJ, Meshnick SR, Crowe SM
Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia.

Abstract

In a cross-sectional study, monocyte subsets in placental, cord, and maternal peripheral blood from pregnant Malawian women with human immunodeficiency virus (HIV)-1 infection and/or malaria were analyzed.

HIV-uninfected Malawian women had higher baseline proportions of CD16(+) monocytes than those reported for healthy adults in developed countries. Malaria was associated with an increase in the proportion of CD16(+) monocytes that was significant in women coinfected with HIV-1. CD16(+) monocytes expressed higher CCR5 levels than did CD14(hi)/CD16(-) monocytes and were significantly more likely to harbor HIV-1.

These data suggest a role for CD16(+) monocytes in the pathogenesis of maternal malaria and HIV-1 infections.

Publication

  • Journal: The Journal of Infectious Diseases
  • Published: 01/07/2007
  • Volume: 196
  • Issue: 1
  • Pagination: 38-42

Health Issue