Publications & Reports

Enhancement of human immunodeficiency virus type 1 replication is not intrinsic to all polyanion-based microbicides.

Sonza S, Johnson A, Tyssen D, Spelman T, Lewis GR, Paull JR, Tachedjian G
Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria 3004, Australia.


Polyanion-based microbicides have been developed to prevent the sexual transmission of human immunodeficiency virus (HIV).

Recent data suggest that polyanions have the capacity to enhance HIV type 1 (HIV-1) replication at threshold antiviral concentrations.

Evaluation of the microbicide candidates SPL7013 and PRO 2000 revealed no specific enhancement of two CCR5 HIV-1 strains in human peripheral blood mononuclear cells compared to enfuvirtide (Fuzeon).

The enhancement effect is likely to be a function of the assay conditions and is not an intrinsic property of these polyanions.


  • Journal: Antimicrobial Agents and Chemotherapy
  • Published: 01/08/2009
  • Volume: 53
  • Issue: 8
  • Pagination: 3565-3568


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