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Polyanion-based microbicides have been developed to prevent the sexual transmission of human immunodeficiency virus (HIV).
Recent data suggest that polyanions have the capacity to enhance HIV type 1 (HIV-1) replication at threshold antiviral concentrations.
Evaluation of the microbicide candidates SPL7013 and PRO 2000 revealed no specific enhancement of two CCR5 HIV-1 strains in human peripheral blood mononuclear cells compared to enfuvirtide (Fuzeon).
The enhancement effect is likely to be a function of the assay conditions and is not an intrinsic property of these polyanions.
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