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Adolescent girls and young women are disproportionately affected by HIV in sub-Saharan Africa where they are up to 8 times more likely to be infected compared to their male counterparts.
A major biological mechanism driving this increased risk is subclinical genital inflammation due to the presence of “non-optimal” vaginal microbiota depleted of beneficial lactobacillus species.
This study aims to develop an intravaginal ring to deliver factors that can ultimately enhance the vaginal environment and microbiota to prevent STIs, including HIV as well as adverse reproductive health outcomes.
Professor Simon Moulton Dr Simon Cook Dr Nina Eikelis