Projects

CT2 Study: Community-based Testing and Treatment for Hepatitis C


Image: (L-R) Dr Win Aung, Professor Margaret Hellard, President (MLF) Professor Khin Pyone Kyi, Dr Yi Yi Sein, Dr Mu Mya at Than Sitt Charity Clinic

Examining feasibility, acceptability, effectiveness and cost-effectiveness of a community-based testing and treatment program for hepatitis C in Myanmar.

The CT2 Study is an effectiveness-implementation hybrid trial assessing the feasibility, acceptability, effectiveness and cost-effectiveness of a community-based testing and treatment program for hepatitis C.


Image: A laboratory assistant taking blood

Two study sites

The study sites are in Yangon, Myanmar: Burnet Institute Thingangyun Clinic and Myanmar Liver Foundation Than Sitt Charity Clinic. These two sites serve people who inject drugs and general population respectively.

Each site provides point-of-care hepatitis C testing using rapid diagnostic test for hepatitis C antibody and the GeneXpert HCV VL test for hepatitis C RNA (with result available in under two hours). Participants with chronic hepatitis C virus infection are then offered direct-acting antiviral therapy. Participants’ treatment work-up is conducted by the generalist doctor at the clinic, with hepatologist support available if required.


Image: Hepatitis C Testing and Treatment Training Workshop, January 2019

This study provides the opportunity to treat up to 450 patients for their hepatitis C in primary care; complementing the National Hepatitis Control Program’s QuickStart treatment program in the tertiary hospitals.

Results

The results of this study will inform any potential scale-up of community-based primary care provision of hepatitis C services in Myanmar and other resource-constrained settings. Preliminary results of the first 250 participants recruited were presented at INHSU Conference in September 2019 with poster available online.


Image: A counselor chats with clients outside the Burnet Institute Thingangyun Clinic

Timeline

  • January 2019 – June 2020
  • Completed intensive training 7th to 11th January 2019
  • Recruitment started 30th of January 2019
  • Recruitment closed 30th of September 2019
  • Results will be available June 2020

Collaborators

Myanmar Liver Foundation (partner)

Funding

Foundation of Innovative and New Diagnostic; Unitaid

Contact Details

For any general enquiries relating to this project, please contact:

Professor Margaret Hellard AM

Deputy Director (Programs); Adjunct Professor, Monash University, DEPM.

Telephone

+61385062304

Email

margaret.hellard@burnet.edu.au