Projects

Functional antibody responses to malaria vaccine candidates

This project focuses on functional antibodies and their ability to inhibit binding of the malaria parasite to red blood cells.

Previous studies have shown that individuals living in malaria endemic areas develop antibodies to the malaria parasite.However, questions remain on how these antibodies function.

One potential function is binding inhibition where antibodies bind to parasite proteins such as EBA 175 and prevent them from interacting with their respective receptors on the red blood cell. Thus, decreasing the ability of the parasite to invade, and therefore lowering the risk of disease.

First binding inhibition assays are developed, these assays are used on antibody samples from individuals living in endemic areas such as Papua New Guinea to further understand:

  • Which parasite antigens are the best targets for binding inhibition?
  • What is the mechanism of binding inhibition?
  • What properties of antibodies are important for binding inhibition?

Health Issue

Contact Details

For any general enquiries relating to this project, please contact:

Doctor Jack Richards

Group Head, NHMRC Postdoctoral Fellow, Infectious Diseases Physician

Telephone

+61385062405

Email

jack.richards@burnet.edu.au