Contacts

Doctor Magdaline Costa

Flow Cytometrist

Background

Magdaline Costa joined the AMREPFlow, Core Flow Cytometry Facility in 2017. Prior to this, she was a post-doctoral scientist for 17 years and worked on a range of projects.

She spent most of her postdoctoral career working with human embryonic stem cells (hESCs) and human induced pluripotent stem (iPS) cells. She successfully generated a gene targeting protocol and differentiated these cells into endothelium.

Recently, iPS cells generated from patients with acute myeloid leukaemia (AML) were used to investigate this disease in vitro.

Positions

  • January 2017-current, Flow Cytometrist, AMREPFlow, Core Flow Cytometry Facility.

  • August 2013-January 2017, Senior Research Officer. Monash University, Australian Centre for Blood Diseases (ACBD). Employer: Associate Professor Jody Haigh. Project title: The generation of induced pluripotent stem (iPS) cells from leukaemic blood samples to investigate mechanisms leading to aberrant haematopoiesis.

  • January 2016-May 2016: Research Officer, Monash University, Australian Regenerative Medicine Institute (ARMI). Employer Andras Nagy. Cellular Reprogramming.

  • February 2002-August 2013: Research Fellow. Monash University, Department of Anatomy and Developmental Biology/Monash Immunology and stem Cell Laboratories (MISCL)/Institute of Reproduction and Development (IRD). Employers: Professor A.G. Elefanty and Professor E.G. Stanley. Project titles: (i) Genetic modification of human embryonic stem cells using homologous recombination; (ii) Generation, characterisation and maturation of endothelial cells (ECs) derived from hESCs and iPS cells (source: fibroblasts from both healthy individuals and patients with familial pulmonary arterial hypertension, PAH).

  • February 2000-February 2002: Research Fellow, Monash University, Department of Medicine, Box Hill Hospital. Employer: Professor R.L. Medcalf. Project title: Mechanisms governing the cell-specific regulation of the human tissue-type plasminogen activator gene.

  • July 1999-February 2000: Research Assistant, Monash University, Department of Medicine, Box Hill Hospital. Employer: Professor R.L. Medcalf. Project title: Mechanisms governing the cell-specific regulation of the human tissue-type plasminogen activator gene.

Qualifications

  • 1993-1994: Bachelor of Science, Monash University,
  • 1995: Bachelor of Science, Honours, Monash University,
  • 1996-1999: PhD, Monash University,

Awards

  • 2010-2012, Qatar National Research Fund. Application ID NPRP09-1087-3-274, Lead PI, Prof. Ed Stanley (Monash, MISCL), Co-Investigators Prof. Andrew Elefanty (Monash, MISCL), Dr David Elliot (Monash MISCL), Dr Magdaline Costa (Monash, MISCL), Prof J. Arash Tabrizi (Weill-Cornell Medical College, Qatar). Cardiovascular progenitors derived from Pluripotent Stem Cells

  • 2003-2005, NHMRC grant number 236862, CI’s Medcalf, RL, Costa, M. Molecular mechanisms for the cell-type specific regulation of the tissue-type plasminogen activator gene

  • 1999-2001, NHMRC grant number 990219, CI’s Medcalf, RL, Costa M. Molecular control of fibrinolysis

Publications (20)

2017 (1)

2016 (2)

2015 (1)

  • ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling.
    Goossens S, Radaelli E, Blanchet O, Durinck K, Van der Meulen J, Peirs S, Taghon T, Tremblay CS, Costa M, Farhang Ghahremani M, De Medts J, Bartunkova S, Haigh K, Schwab C, Farla N, Pieters T, Matthijssens F, Van Roy N, Best JA, Deswarte K, Bogaert P, Carmichael C, Rickard A, Suryani S, Bracken LS, Alserihi R, Canté-Barrett K, Haenebalcke L, Clappier E, Rondou P, Slowicka K, Huylebroeck D, Goldrath AW, Janzen V, McCormack MP, Lock RB, Curtis DJ, Harrison C, Berx G, Speleman F, Meijerink JP, Soulier J, Van Vlierberghe P, Haigh JJ
    Nat Commun. 2015 Jan; 6:5794

2014 (1)

2013 (1)

2012 (1)

2009 (1)

2008 (3)

2007 (1)

2005 (2)

2001 (2)

2000 (1)

1998 (1)

1997 (1)

1996 (1)

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Contact Details

Telephone

+61385062332

Email

magdaline.costa@burnet.edu.au