Viewpoints on HIV reservoirs

Angus Morgan

11 December, 2015

Burnet Institute Principal Fellow and HIV Neuropathogenesis Laboratory Head, Associate Professor Melissa Churchill, has contributed to a commentary on HIV reservoirs published in the prestigious journal Nature Reviews Microbiology.

One of the main challenges in the fight against HIV infection is to develop strategies to eliminate the reservoir that harbours integrated, replication-competent provirus within host cellular DNA.

This reservoir is resistant to antiretroviral therapy (ART) and to clearance by the immune system of the host.

Viruses originating from this reservoir lead to rebound viraemia once treatment is stopped, giving rise to new rounds of infection.

Several studies have focused on elucidating the cells and tissues that harbour persistent virus, the true size of the reservoir and how best to target it, but these topics are the subject of ongoing debate.

In this Viewpoint article, Associate Professor Churchill is one of five experts in the field invited to discuss the constitution of the viral reservoir, how best to measure it and the best ways to target this source of persistent infection.

Associate Professor Churchill focused on HIV infection of the central nervous system and brain tissue.

To read the article entitled HIV reservoirs: what, where and how to target them click here.

Contact Details

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Burnet Institute

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