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Regulatory T-cells: immunomodulators in health and disease.

Scalzo K, Plebanski M, Apostolopoulos V

  • Journal Current topics in medicinal chemistry

  • Published 04 Dec 2006

  • Volume 6

  • ISSUE 16

  • Pagination 1759-68

  • DOI 10.2174/156802606778194262


Regulation of immune responses is crucial in order to maintain immunological self-tolerance. This is maintained in the periphery by a number of cell types that have the capacity to control and regulate immune responses, thus preventing reactivity to self while monitoring appropriate, non-exuberant responses to non-self-antigens. The various mechanisms of regulation will be discussed in this review together with how this knowledge could be used to develop better drugs and treatments for various diseases.