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Proapoptotic functions of cytotoxic lymphocyte granule constituents in vitro and in vivo.

Trapani JA, Davis J, Sutton VR, Smyth MJ

  • Journal Current opinion in immunology

  • Published 13 Jun 2000

  • Volume 12

  • ISSUE 3

  • Pagination 323-9

  • DOI 10.1016/s0952-7915(00)00094-7


Recent advances in our understanding of cytolytic effector mechanisms include the partial characterization of caspase-independent apoptotic pathways triggered by granzymes, a realization of the vital importance of perforin and granzymes in the defence against certain virus infections in vivo and the first description of hereditary immunodeficiency due to disordered perforin expression in humans.