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Prevalence of antibodies to hepatitis E virus in residents of a district in Havana, Cuba.

Quintana A, Sanchez L, Larralde O, Anderson D

  • Journal Journal of medical virology

  • Published 29 Aug 2005

  • Volume 76

  • ISSUE 1

  • Pagination 69-70

  • DOI 10.1002/jmv.20324


A seroepidemiological study of hepatitis E virus (HEV) infection was conducted in a district of Havana, where hepatitis A virus (HAV) is considered endemic. The levels of anti-HEV antibodies were evaluated by enzyme-linked immunosorbent assay (ELISA) based on the recombinant protein GST-ORF2.1. Anti-HEV antibodies were detected in 11 of 209 (5.3%) of serum samples, compared to 71.3% for anti-HAV antibodies. No risk factors reported previously for HEV infection showed a significant association with the presence of anti-HEV antibodies, whereas anti-HAV antibodies were strongly associated with increasing age. HEV may be considered endemic in this area and is likely to have a significant clinical impact.