close Icon

Decreased in vitro susceptibility to zidovudine of HIV isolates obtained from patients with AIDS.

Land S, Terloar G, McPhee D, Birch C, Doherty R, Cooper D, Gust I

  • Journal The Journal of infectious diseases

  • Published 09 Mar 1990

  • Volume 161

  • ISSUE 2

  • Pagination 326-9

  • DOI 10.1093/infdis/161.2.326


This study tested isolates of human immunodeficiency virus, obtained before and after zidovudine therapy from 10 patients, for susceptibility to the drug in vitro. The isolates collected after therapy were less susceptible to zidovudine as assessed by replication in MT-2 cells and production of reverse transcriptase activity by infected mononuclear leucocytes in the presence of the drug. Furthermore, pretherapy isolates were sensitive to a range of zidovudine concentrations when 100% inhibition was used as the end point. The loss of zidovudine susceptibility did not correlate with any clinical or virologic consequences in this small group of patients.