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A compilation of cellular transcription factor interactions with the HIV-1 LTR promoter.

Pereira LA, Bentley K, Peeters A, Churchill MJ, Deacon NJ

  • Journal Nucleic acids research

  • Published 06 Mar 2000

  • Volume 28

  • ISSUE 3

  • Pagination 663-8

  • DOI 10.1093/nar/28.3.663


The human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) represents a model promoter system and the identification and characterisation of cellular proteins that interact with this region has provided a basic understanding about both general eukaryotic and HIV-1 proviral transcriptional regulation. To date a large number of sequence-specific DNA-protein interactions have been described for the HIV-1 LTR. The aim of this report is to provide a comprehensive, updated listing of these HIV-1 LTR interactions. It is intended as a reference point to facilitate on-going studies characterising the identity of cellular proteins interacting with the HIV-1 LTR and the functional role(s) of specific regions of the LTR for HIV-1 replication.